Investigation of the Effects of Dietary Ingestion of Perfluorbutane Sulfonate (PFBS) on Adipose Tissues
Faculty Mentor
Gato, Eric
Location
Russell Union Ballroom
Type of Research
On-going
Session Format
Oral Presentation
College
Honors College
Department
Biology
Abstract
Per- and polyfluoroalkyl substances (PFAS) are chemical substances used in a variety of industrial applications and consumer products. Perfluorobutane sulfonate (PFBS) is often used as a replacement for the more harmful (Perfluoroalkyl sulfonate) PFAS chemicals that have been around longer. Due to the fact that PFBS does stay in the body as long, there is a rising concern that it has the potential to cause damage to human health. This study focused on understanding how dietary PFBS exposure affects the adipose tissues in rats because PFBS plays an important role in metabolism. To accomplish study objectives, Sprague Dawley rats were exposed to different levels of PFBS (0ppm, 50ppm, and 100ppm) for 11 weeks. At the end of the treatment period, the rats were sacrificed. The adipose tissues (AT), blood serum and other organs were harvested for further analysis. The level of triglycerides in AT was dose-dependently elevated. In contrast, antioxidant capacity was reduced in AT homogenates of rats that consumed PFBS. The percent NFKB was reduced in treated groups. Further analysis of mRNA transcripts related to inflammation, immune and other cellular processes is under consideration. These measurements will enable us to elucidate how PFBS could affect energy storage and regulation in adipose tissues. It is anticipated that results will be dose dependent.
Program Description
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Start Date
4-23-2026 10:00 AM
End Date
4-23-2026 12:00 PM
Recommended Citation
Olofintuyi, Hannah; Olofintuyi, Hannah; Cooper, Skylar; Williams, Gamyzhae; and Gato, Eric, "Investigation of the Effects of Dietary Ingestion of Perfluorbutane Sulfonate (PFBS) on Adipose Tissues" (2026). GS4 Student Scholars Symposium. 99.
https://digitalcommons.georgiasouthern.edu/research_symposium/2026/2026/99
Investigation of the Effects of Dietary Ingestion of Perfluorbutane Sulfonate (PFBS) on Adipose Tissues
Russell Union Ballroom
Per- and polyfluoroalkyl substances (PFAS) are chemical substances used in a variety of industrial applications and consumer products. Perfluorobutane sulfonate (PFBS) is often used as a replacement for the more harmful (Perfluoroalkyl sulfonate) PFAS chemicals that have been around longer. Due to the fact that PFBS does stay in the body as long, there is a rising concern that it has the potential to cause damage to human health. This study focused on understanding how dietary PFBS exposure affects the adipose tissues in rats because PFBS plays an important role in metabolism. To accomplish study objectives, Sprague Dawley rats were exposed to different levels of PFBS (0ppm, 50ppm, and 100ppm) for 11 weeks. At the end of the treatment period, the rats were sacrificed. The adipose tissues (AT), blood serum and other organs were harvested for further analysis. The level of triglycerides in AT was dose-dependently elevated. In contrast, antioxidant capacity was reduced in AT homogenates of rats that consumed PFBS. The percent NFKB was reduced in treated groups. Further analysis of mRNA transcripts related to inflammation, immune and other cellular processes is under consideration. These measurements will enable us to elucidate how PFBS could affect energy storage and regulation in adipose tissues. It is anticipated that results will be dose dependent.
