Synthesis of TU100 Analogs by Reductive Dealkylation Using Hydrogenation Conditions
Faculty Mentor
Dr. John DiCesare
Location
Russell Union Ballroom
Type of Research
On-going
Session Format
Poster Presentation
College
College of Science & Mathematics
Department
Department of Chemistry
Abstract
TU100 is a naphthoquinone adduct from a 3+2 cycloaddition reaction between N-methyl-4-hydroxylisoquinolinium and 1,4-naphthoquinone, following the method established by DiCesare et al. Current research focuses on synthesizing TU100 analogs. Modification of the TU100 compound by removing the N-methyl group and reduction of the benzo-carbonyl are being explored. After extraction of the reaction mixtures, flash column chromatography was employed to separate the product from remaining starting materials, followed by nuclear magnetic resonance (NMR) spectroscopy to assess purity. Thin-layer chromatography (TLC) was frequently used to monitor reaction progress. Expanding the library of TU100 analogs is crucial in getting an analog with optimized biological activity and enhanced potential as chemotherapeutic agents.
Program Description
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Start Date
4-23-2026 10:00 AM
End Date
4-23-2026 12:00 PM
Recommended Citation
Sellards, Keira Joy, "Synthesis of TU100 Analogs by Reductive Dealkylation Using Hydrogenation Conditions" (2026). GS4 Student Scholars Symposium. 68.
https://digitalcommons.georgiasouthern.edu/research_symposium/2026/2026/68
Synthesis of TU100 Analogs by Reductive Dealkylation Using Hydrogenation Conditions
Russell Union Ballroom
TU100 is a naphthoquinone adduct from a 3+2 cycloaddition reaction between N-methyl-4-hydroxylisoquinolinium and 1,4-naphthoquinone, following the method established by DiCesare et al. Current research focuses on synthesizing TU100 analogs. Modification of the TU100 compound by removing the N-methyl group and reduction of the benzo-carbonyl are being explored. After extraction of the reaction mixtures, flash column chromatography was employed to separate the product from remaining starting materials, followed by nuclear magnetic resonance (NMR) spectroscopy to assess purity. Thin-layer chromatography (TLC) was frequently used to monitor reaction progress. Expanding the library of TU100 analogs is crucial in getting an analog with optimized biological activity and enhanced potential as chemotherapeutic agents.
