Impact of dietary perfluorobutane sulfonate (PFBS) on the brain of Sprague Dawley rats
Faculty Mentor
Dr. Eric Gato
Location
Russell Union Ballroom
If Other was choses above, please indicate your topic area here:
Chemistry/Biochemistry
Type of Research
Proposed
Session Format
Poster Presentation
College
College of Science & Mathematics
Department
Chemistry, Biochemistry and Physics
Abstract
Perfluorobutane sulfonate, or PFBS, is a common flame-resistant chemical found in a variety of consumer products. It is known as a “forever chemical” due to its robust nature and inability to be easily broken down. Numerous experiments have been performed exploring the toxicity linked to PFBS. Studies on PFBS’ effect on human health remain underway. The objective of this research is to investigate the effects of PFBS ingestion on the brain of Sprague Dawley rats. Several methods of research will and have been used to analyze brain tissues of rats that have ingested varying amount of PFBS. These varying amounts are 0 ppm, 50 ppm and 100 ppm. Primary investigation will include study of specific genes that when over or under expressed, can suggest oxidative stress in the brain. The expected result of experimentation would be that rats with exposure to the higher dosage of PFBS (100 ppm) would show a more extreme difference in target gene expression than rats exposed to the lower dosage of PFBS (50 ppm), both exhibiting higher genetic responses than rats who received 0 ppm PFBS. These results would indicate PFBS toxicity as well as short-term and long-term effects of PFBS exposure.
Program Description
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Start Date
4-23-2026 2:00 PM
End Date
4-23-2026 4:00 PM
Recommended Citation
Connelly, Sydney E., "Impact of dietary perfluorobutane sulfonate (PFBS) on the brain of Sprague Dawley rats" (2026). GS4 Student Scholars Symposium. 158.
https://digitalcommons.georgiasouthern.edu/research_symposium/2026/2026/158
Impact of dietary perfluorobutane sulfonate (PFBS) on the brain of Sprague Dawley rats
Russell Union Ballroom
Perfluorobutane sulfonate, or PFBS, is a common flame-resistant chemical found in a variety of consumer products. It is known as a “forever chemical” due to its robust nature and inability to be easily broken down. Numerous experiments have been performed exploring the toxicity linked to PFBS. Studies on PFBS’ effect on human health remain underway. The objective of this research is to investigate the effects of PFBS ingestion on the brain of Sprague Dawley rats. Several methods of research will and have been used to analyze brain tissues of rats that have ingested varying amount of PFBS. These varying amounts are 0 ppm, 50 ppm and 100 ppm. Primary investigation will include study of specific genes that when over or under expressed, can suggest oxidative stress in the brain. The expected result of experimentation would be that rats with exposure to the higher dosage of PFBS (100 ppm) would show a more extreme difference in target gene expression than rats exposed to the lower dosage of PFBS (50 ppm), both exhibiting higher genetic responses than rats who received 0 ppm PFBS. These results would indicate PFBS toxicity as well as short-term and long-term effects of PFBS exposure.
