Rational drug design, synthesis and antibacterial activity evaluation of novel Linezolid analogues
Faculty Mentor
Abid Shaikh
Location
Russell Union Ballroom
Type of Research
On-going
Session Format
Poster Presentation
College
College of Science & Mathematics
Department
Biochemistry, Chemistry and Physics
Abstract
Developing new antibiotics to combat multidrug-resistant bacteria and achieve broad-spectrum activity remains at the forefront of chemical research. The molecular hybridization approach could be an effective strategy to develop potential drug candidates by modifying the known scaffolds. We planned a rational design and synthesis of novel Linezolid analogues by incorporating other known antibacterial cores at two different sites. Later, these compounds were tested for in vitro antimicrobial activity evaluation. We carried out multi-step synthesis of Linezolid core utilizing the reported literature methods. All the intermediates and the final products were isolated in high analytical purity and fully characterized using H/C-NMR spectroscopy.
Program Description
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Start Date
4-23-2026 2:00 PM
End Date
4-23-2026 4:00 PM
Recommended Citation
Shaikh, Abid and Bernard, Patrick, "Rational drug design, synthesis and antibacterial activity evaluation of novel Linezolid analogues" (2026). GS4 Student Scholars Symposium. 148.
https://digitalcommons.georgiasouthern.edu/research_symposium/2026/2026/148
Rational drug design, synthesis and antibacterial activity evaluation of novel Linezolid analogues
Russell Union Ballroom
Developing new antibiotics to combat multidrug-resistant bacteria and achieve broad-spectrum activity remains at the forefront of chemical research. The molecular hybridization approach could be an effective strategy to develop potential drug candidates by modifying the known scaffolds. We planned a rational design and synthesis of novel Linezolid analogues by incorporating other known antibacterial cores at two different sites. Later, these compounds were tested for in vitro antimicrobial activity evaluation. We carried out multi-step synthesis of Linezolid core utilizing the reported literature methods. All the intermediates and the final products were isolated in high analytical purity and fully characterized using H/C-NMR spectroscopy.
