(Diethylamino)sulfur trifluoride (DAST)-mediated synthesis of bis(indolyl)methanes (BIM) from benzyl alcohols and amines
Faculty Mentor
Abid Shaikh
Location
Russell Union Ballroom
Type of Research
On-going
Session Format
Poster Presentation
College
College of Science & Mathematics
Department
Biochemistry, Chemistry and Physics
Abstract
Bis(indolyl)methanes (BIM) and related compounds are important nitrogen-containing motif that are present in a variety of natural products and commercial products. Moreover, BIM and its analogues display a range of biological and pharmacological activities such as anti-inflammatory, antifungal, antioxidant, antibacterial, pain killer and antibiotic properties.We planned the synthesis of these important compounds by reacting benzyl alcohol and amine and N-methylindole as model substrates with DAST and DMSO as a reagent/solvent system. To further optimize the reaction conditions, we investigated the progress of the reaction at different time intervals. A range of indole derivatives were investigated to broaden the scope of the synthetic strategy. The major advantages of this process are the use commercially available starting materials and reagents.
Program Description
.
Start Date
4-23-2026 2:00 PM
End Date
4-23-2026 4:00 PM
Recommended Citation
Shaikh, Abid and Pathan, Saniyah, "(Diethylamino)sulfur trifluoride (DAST)-mediated synthesis of bis(indolyl)methanes (BIM) from benzyl alcohols and amines" (2026). GS4 Student Scholars Symposium. 145.
https://digitalcommons.georgiasouthern.edu/research_symposium/2026/2026/145
(Diethylamino)sulfur trifluoride (DAST)-mediated synthesis of bis(indolyl)methanes (BIM) from benzyl alcohols and amines
Russell Union Ballroom
Bis(indolyl)methanes (BIM) and related compounds are important nitrogen-containing motif that are present in a variety of natural products and commercial products. Moreover, BIM and its analogues display a range of biological and pharmacological activities such as anti-inflammatory, antifungal, antioxidant, antibacterial, pain killer and antibiotic properties.We planned the synthesis of these important compounds by reacting benzyl alcohol and amine and N-methylindole as model substrates with DAST and DMSO as a reagent/solvent system. To further optimize the reaction conditions, we investigated the progress of the reaction at different time intervals. A range of indole derivatives were investigated to broaden the scope of the synthetic strategy. The major advantages of this process are the use commercially available starting materials and reagents.
