Presentation Title

Multifunctional Copolymers for Hemoglobin Based Treatment of Severe Traumatic Brain Injuries

Location

Atrium

Session Format

Poster Presentation

Research Area Topic:

Natural & Physical Sciences - Chemistry

Co-Presenters, Co- Authors, Co-Researchers, Mentors, or Faculty Advisors

Helen Saenz, Carl Jones, Dr. Hans-Joerg Schanz

Abstract

Injuries associated with significant blood loss, such as traumatic brain injury (TBI), inevitably result in oxygen deficiency, affecting all human tissue and organs. The following research efforts aim to decrease the mortality and long-term damage rate of TBI patients by synthesizing a storable and readily available hemoglobin-based oxygen carrier (HBOC). Clinical trials have shown that cell-free HBOCs actually increase the mortality rate by inducing a neurotoxic effect due to their oxidative nature. The attachment of 2,2,6,6-tetramethylpiperidine-1-oxidyl (TEMPO), a reducing agent, as well as polyethylene glycol (PEG) units to the protein shell of hemoglobin increases biocompatibility and reduces the oxidative nature of HBOC. The applied procedure is a controlled ring opening metathesis polymerization (ROMP) with Ru-alkylidene catalysts. This modular synthesis of multifunctional polymers allows for variable ratios of TEMPO and PEG density at the HBOC. The application of these polymers should significantly enhance the current state of the art as the presented approach could dramatically improve the cost benefit ratio for the PNPH’s. We will be presenting the synthetic strategy and initial results.

Keywords

Hemoglobin, Traumatic, Braininjuries, 2, 2, 6, 6-tetramethylpiperidine-1-oxidyl, HBOC, TEMPO

Presentation Type and Release Option

Presentation (Open Access)

Start Date

4-24-2015 2:45 PM

End Date

4-24-2015 4:00 PM

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Apr 24th, 2:45 PM Apr 24th, 4:00 PM

Multifunctional Copolymers for Hemoglobin Based Treatment of Severe Traumatic Brain Injuries

Atrium

Injuries associated with significant blood loss, such as traumatic brain injury (TBI), inevitably result in oxygen deficiency, affecting all human tissue and organs. The following research efforts aim to decrease the mortality and long-term damage rate of TBI patients by synthesizing a storable and readily available hemoglobin-based oxygen carrier (HBOC). Clinical trials have shown that cell-free HBOCs actually increase the mortality rate by inducing a neurotoxic effect due to their oxidative nature. The attachment of 2,2,6,6-tetramethylpiperidine-1-oxidyl (TEMPO), a reducing agent, as well as polyethylene glycol (PEG) units to the protein shell of hemoglobin increases biocompatibility and reduces the oxidative nature of HBOC. The applied procedure is a controlled ring opening metathesis polymerization (ROMP) with Ru-alkylidene catalysts. This modular synthesis of multifunctional polymers allows for variable ratios of TEMPO and PEG density at the HBOC. The application of these polymers should significantly enhance the current state of the art as the presented approach could dramatically improve the cost benefit ratio for the PNPH’s. We will be presenting the synthetic strategy and initial results.