Electrospinning of Cisplatin-Loaded Cellulose Nanofibers for Cancer Drug Delivery
Proceedings of the ASME 2014 International Mechanical Engineering Congress & Exposition, IMECE2014
Cellulosic nanofibers have been electrospun with an antitumor agent Cisplatin. Cellulose acetate (CA) and Cisplatin were co-electrospun using a coaxial electrospinning system. For the outer sheath, a solution of 7.5wt% CA in Acetone and DMAc (2:1) was used. The inner core consisted of Cisplatin dissolved in DMF at a concentration of 5mg/ml. Drug-loaded nanofibers from Cellulose pulp (2wt%) dissolved in NMMO. H2O were also produced. The solutions were electrospun in a high voltage electric field of 25–30 kV. Characterization of neat and drug-loaded nanofibers was performed using Scanning electron microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS). The characterization studies have shown the formation of nanofibers having both sporadic beads with internal agglomeration and conjugation of Cisplatin on the nanofiber surfaces.
Absar, Saheem, Mujibur R. Khan, Kyle Edwards, David M. Calamas.
"Electrospinning of Cisplatin-Loaded Cellulose Nanofibers for Cancer Drug Delivery."
Proceedings of the ASME 2014 International Mechanical Engineering Congress & Exposition, IMECE2014 Montreal, Quebec, Canada.