Physical Properties of Vanillin-tetraphenylporhyrin and Its Potential Applications in Photodynamic Therapy

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Photodynamic Therapy (PDT) is a technique used for the treatment of various types of illnesses. In our project we use Vanillin-Tetraphenylporphyrin (Vanillin-TPP), which is a compound derived condensing Vanillin together with pyrrol to form the Porphyrin macrocycle. We have measured and quantified the of Vanillin-TPP promoted photolysis of 9,10 Diphenylanthracene (DPA) in Acetonitrile. When exposed to light of 514 nm wavelength (50 mW), DPA is virtually eliminated from the solution in two hours time. A secondary goal of the project is to establish the mechanism of the reaction that is taking place during the photolysis. So far we have been able to show that the reaction is of second order in Vanillin-TPP, first order in DPA, and strongly depends on the presence of Oxygen. Future work will include photolysis on cancer cell cultures.


American Chemical Society Annual Meeting (ACS)


New Orleans, LA