Synthesis, Characterization and Cell Viability of Novel Tripodal Amines
Location
Statesboro Campus (Room 2054)
Document Type and Release Option
Thesis Presentation (Open Access)
Faculty Mentor
Dr. Christine Whitlock
Faculty Mentor Email
cwhitlock@georgiasouthern.edu
Presentation Year
2022
Start Date
16-11-2022 6:00 PM
End Date
16-11-2022 7:00 PM
Description
Cancer, over the years, has become a much more prevalent focus for the scientific community. Organizations and laboratories all over the world have spent countless hours searching for a cure, trying to learn more about what makes cancer so powerful and what is the best way to stop its growth. Iron-chelation drugs were already on the market, and it was shown that they did have the ability to act as both iron-chelators and anticancer drugs. Most of these iron-chelating drugs are not as effective at killing cancer cells as the medical field desires. Novel iron-chelating tris-indolyl derivatives, GSO2, GSO4 and GSO6, were synthesized and tested for their potential anti-cancer properties. These compounds were characterized using both melting points and NMR. Apoptosis was the chosen method for cell death of the PC3 cells. The compounds, GSO2 and GSO4 did show promising results when tested on human prostate cancer cell lines. The success of these compounds does sanction further research into apoptosis of other human cancer cell lines.
Academic Unit
College of Science and Mathematics
Synthesis, Characterization and Cell Viability of Novel Tripodal Amines
Statesboro Campus (Room 2054)
Cancer, over the years, has become a much more prevalent focus for the scientific community. Organizations and laboratories all over the world have spent countless hours searching for a cure, trying to learn more about what makes cancer so powerful and what is the best way to stop its growth. Iron-chelation drugs were already on the market, and it was shown that they did have the ability to act as both iron-chelators and anticancer drugs. Most of these iron-chelating drugs are not as effective at killing cancer cells as the medical field desires. Novel iron-chelating tris-indolyl derivatives, GSO2, GSO4 and GSO6, were synthesized and tested for their potential anti-cancer properties. These compounds were characterized using both melting points and NMR. Apoptosis was the chosen method for cell death of the PC3 cells. The compounds, GSO2 and GSO4 did show promising results when tested on human prostate cancer cell lines. The success of these compounds does sanction further research into apoptosis of other human cancer cell lines.
