Document Type and Release Option
Thesis (open access)
Dr. Hans-Joerg Schanz
Polyethylene glycol (PEG) has shown the ability to improve compatibility when used in combination with cell-free hemoglobin in the treatment of traumatic brain injuries. It has been demonstrated that the covalently bonded PEG increases the hydrodynamic radius of the hemoglobin and hence generates a physical barrier while slowing down the oxygen delivery of the strongly oxidative hemoglobin. In this context, I have been working on the development of synthetic pathways to incorporate PEG into monomers and polymers through both direct modification of (7-oxa)norbornene derivatives and post polymerization modification. Starting from the (7-oxa)norbornene anhydride derivatives, we have developed pathways to cationic and uncharged monomers which can be polymerized via Ring Opening Metathesis Polymerization (ROMP) using Grubbs 1st and 3rd generation-type Ru-alkylidene complexes. These complexes are known to produce ROMPolymers with high molecular weight control. In this context, we also developed a chain transfer agent to introduce a functional end group into the polymer which will enable the covalent binding of the polymer to the hemoglobin protein.
McCollum, Andrea L., "Polyethylene Glycol containing ROMPolymers for the Modification of Neuro-Protective Hemoglobin" (2014). University Honors Program Theses. 34.