Honors College Theses
Publication Date
2025
Major
Biology (B.S.B.)
Release Option
Open Access
Faculty Mentor
Shainaz Landge; Sara Gremillion
Abstract
Triazoles have diverse applications, including antibacterial, and antitumor agents, as well as textile dyes. The click chemistry approach was used to develop a microwave-assisted synthesis of biologically active triazole molecules. Microwave assistance enables a more economically as well as environmentally friendly, and time-efficient reaction. Reaction efficacy was assessed via percent yield, while qualitative analysis was conducted using hydrogen NMR, carbon NMR, and IR spectroscopy. The triazole core was linked to an aromatic center at the 1 and 4 positions. Nine different triazole derivatives with variable substituents at the 4-position were synthesized. These substituents feature aromatic centers with carbonyl functional groups at ortho, meta, or para positions. The synthesized compounds were screened for antibacterial and antifungal activity.
Thesis Summary
This thesis focuses on the development and characterization of carbonyl appended 1,2,3-triazoles, and analyzes some of their biological implications.
Recommended Citation
Melvin, Charles, "Biological evaluation of various carbonyl appended derivatives on a hydroaromatic 1,2,3-Triazole core structure." (2025). Honors College Theses. 1039.
https://digitalcommons.georgiasouthern.edu/honors-theses/1039
