Exploring Medicinal Applications of Pyridoxine-Latnthanides
Primary Faculty Mentor’s Name
Dr. Arpita Saha
Proposal Track
Student
Session Format
Poster
Abstract
Lanthanide complexes have drawn significant attention to medicinal inorganic chemists since lanthanides manifest antitumor activity and lead towards future anticancer drugs. On the other side heterocyclic compounds are often explored in drug discovery and development. Combing the best properties from both ends, the new generation metal complexes using the ligand from the biological world assure promising outcomes for developing new materials with tailored architecture and properties. One such ligand is Vitamin-B6 (Pyridoxin), an essential vitamin which displays several coordination modes with different charges and hard/soft behavior. Pyridoxal containing metal complexes are potential candidates for therapeutic purposes. Herein, the initial reactivity alcohol based chelate, pyridoxine, has been investigated in lanthanide metal chemistry where Gadolinium is the metal of choice. The synthesis, crystal structure, spectroscopic characterizations like IR, UV-Vis, 1 H NMR, EPR studies have reported for Gd-pyridoxin complex. The DNA binding and cleavage characteristics of the synthesized complex were studied as well.
Keywords
Lanthanide, Ligand, Antitumor activity, Medicinal, Inorganic, Crystals
Award Consideration
1
Location
Concourse/Atrium
Presentation Year
2014
Start Date
11-15-2014 9:40 AM
End Date
11-15-2014 10:55 AM
Publication Type and Release Option
Presentation (Open Access)
Recommended Citation
Stouder, Caitlyn E., "Exploring Medicinal Applications of Pyridoxine-Latnthanides" (2014). Georgia Undergraduate Research Conference (2014-2015). 23.
https://digitalcommons.georgiasouthern.edu/gurc/2014/2014/23
Exploring Medicinal Applications of Pyridoxine-Latnthanides
Concourse/Atrium
Lanthanide complexes have drawn significant attention to medicinal inorganic chemists since lanthanides manifest antitumor activity and lead towards future anticancer drugs. On the other side heterocyclic compounds are often explored in drug discovery and development. Combing the best properties from both ends, the new generation metal complexes using the ligand from the biological world assure promising outcomes for developing new materials with tailored architecture and properties. One such ligand is Vitamin-B6 (Pyridoxin), an essential vitamin which displays several coordination modes with different charges and hard/soft behavior. Pyridoxal containing metal complexes are potential candidates for therapeutic purposes. Herein, the initial reactivity alcohol based chelate, pyridoxine, has been investigated in lanthanide metal chemistry where Gadolinium is the metal of choice. The synthesis, crystal structure, spectroscopic characterizations like IR, UV-Vis, 1 H NMR, EPR studies have reported for Gd-pyridoxin complex. The DNA binding and cleavage characteristics of the synthesized complex were studied as well.
