Proposal Title

Exploring Medicinal Applications of Pyridoxine-Latnthanides

Primary Faculty Mentor’s Name

Dr. Arpita Saha

Proposal Track

Student

Session Format

Poster

Abstract

Lanthanide complexes have drawn significant attention to medicinal inorganic chemists since lanthanides manifest antitumor activity and lead towards future anticancer drugs. On the other side heterocyclic compounds are often explored in drug discovery and development. Combing the best properties from both ends, the new generation metal complexes using the ligand from the biological world assure promising outcomes for developing new materials with tailored architecture and properties. One such ligand is Vitamin-B6 (Pyridoxin), an essential vitamin which displays several coordination modes with different charges and hard/soft behavior. Pyridoxal containing metal complexes are potential candidates for therapeutic purposes. Herein, the initial reactivity alcohol based chelate, pyridoxine, has been investigated in lanthanide metal chemistry where Gadolinium is the metal of choice. The synthesis, crystal structure, spectroscopic characterizations like IR, UV-Vis, 1 H NMR, EPR studies have reported for Gd-pyridoxin complex. The DNA binding and cleavage characteristics of the synthesized complex were studied as well.

Keywords

Lanthanide, Ligand, Antitumor activity, Medicinal, Inorganic, Crystals

Award Consideration

1

Location

Concourse/Atrium

Presentation Year

2014

Start Date

11-15-2014 9:40 AM

End Date

11-15-2014 10:55 AM

Publication Type and Release Option

Presentation (Open Access)

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Nov 15th, 9:40 AM Nov 15th, 10:55 AM

Exploring Medicinal Applications of Pyridoxine-Latnthanides

Concourse/Atrium

Lanthanide complexes have drawn significant attention to medicinal inorganic chemists since lanthanides manifest antitumor activity and lead towards future anticancer drugs. On the other side heterocyclic compounds are often explored in drug discovery and development. Combing the best properties from both ends, the new generation metal complexes using the ligand from the biological world assure promising outcomes for developing new materials with tailored architecture and properties. One such ligand is Vitamin-B6 (Pyridoxin), an essential vitamin which displays several coordination modes with different charges and hard/soft behavior. Pyridoxal containing metal complexes are potential candidates for therapeutic purposes. Herein, the initial reactivity alcohol based chelate, pyridoxine, has been investigated in lanthanide metal chemistry where Gadolinium is the metal of choice. The synthesis, crystal structure, spectroscopic characterizations like IR, UV-Vis, 1 H NMR, EPR studies have reported for Gd-pyridoxin complex. The DNA binding and cleavage characteristics of the synthesized complex were studied as well.