Proposal Title

Synthesis of Unusual Trifluoromethylated Amino Acids via Electrophilic Addition of 2-Methyl Azaarenes with α-Trifluoromethylimino Esters

Primary Faculty Mentor’s Name

Shaikh, Abid

Proposal Track

Student

Session Format

Poster

Abstract

Synthesis of unusual trifluoromethylated amino acids is described. Csp3-H functionalization of alkyl group directly attached to aromatic ring with a-iminoesters via electrophilic aminoalkylation is a viable approach for the synthesis of trifluoromethylated amino acids. The synthesis of racemic amino acids was achieved using catalytic amount of triflic acid under mild reaction conditions.

Location

Concourse/Atrium

Presentation Year

2014

Start Date

11-15-2014 9:40 AM

End Date

11-15-2014 10:55 AM

Publication Type and Release Option

Presentation (Open Access)

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Nov 15th, 9:40 AM Nov 15th, 10:55 AM

Synthesis of Unusual Trifluoromethylated Amino Acids via Electrophilic Addition of 2-Methyl Azaarenes with α-Trifluoromethylimino Esters

Concourse/Atrium

Synthesis of unusual trifluoromethylated amino acids is described. Csp3-H functionalization of alkyl group directly attached to aromatic ring with a-iminoesters via electrophilic aminoalkylation is a viable approach for the synthesis of trifluoromethylated amino acids. The synthesis of racemic amino acids was achieved using catalytic amount of triflic acid under mild reaction conditions.