Synthesis of Unusual Trifluoromethylated Amino Acids via Electrophilic Addition of 2-Methyl Azaarenes with α-Trifluoromethylimino Esters
Primary Faculty Mentor’s Name
Shaikh, Abid
Proposal Track
Student
Session Format
Poster
Abstract
Synthesis of unusual trifluoromethylated amino acids is described. Csp3-H functionalization of alkyl group directly attached to aromatic ring with a-iminoesters via electrophilic aminoalkylation is a viable approach for the synthesis of trifluoromethylated amino acids. The synthesis of racemic amino acids was achieved using catalytic amount of triflic acid under mild reaction conditions.
Location
Concourse/Atrium
Presentation Year
2014
Start Date
11-15-2014 9:40 AM
End Date
11-15-2014 10:55 AM
Publication Type and Release Option
Presentation (Open Access)
Recommended Citation
Blocker, Mark, "Synthesis of Unusual Trifluoromethylated Amino Acids via Electrophilic Addition of 2-Methyl Azaarenes with α-Trifluoromethylimino Esters" (2014). Georgia Undergraduate Research Conference (2014-2015). 22.
https://digitalcommons.georgiasouthern.edu/gurc/2014/2014/22
Synthesis of Unusual Trifluoromethylated Amino Acids via Electrophilic Addition of 2-Methyl Azaarenes with α-Trifluoromethylimino Esters
Concourse/Atrium
Synthesis of unusual trifluoromethylated amino acids is described. Csp3-H functionalization of alkyl group directly attached to aromatic ring with a-iminoesters via electrophilic aminoalkylation is a viable approach for the synthesis of trifluoromethylated amino acids. The synthesis of racemic amino acids was achieved using catalytic amount of triflic acid under mild reaction conditions.
