Proposal Title

Controlled Drug Release from Temperature Responsive Core-Shell Nanofibers

Primary Faculty Mentor’s Name

Ji Wu

Proposal Track

Student

Session Format

Poster

Abstract

Drug delivery systems are playing an important role in the fields of medical and pharmaceutical sciences. A sustained and controlled release of drug molecules is critically important to tissue engineering and effective treatment of many diseases, ranging from arthritis to cancer therapies. In the past decade, advanced nanotechnology and nanoscience have been extensively applied to the fabrication of smart materials which can controllably release drug molecules. A common problem in drug delivery system is known as burst effect, which is most likely due to the rapid release of surface associated drug molecules. Another challenge is to realize a programmable drug delivery with variable dosing rates. Modern electrospinning technology allows for drug diffusion studies to be well controlled by tuning spinning parameters and materials. The cost, diameter, composition and structure of electrospun nanofibers can be facilely varied to regulate the drug delivery rates and kinetics. Herein, core-shell nanofibers composed of temperature-responsive core and biodegradable polymeric shell can be utilized for ‘on-demand’ and controlled drug release without burst effect for potential pharmaceutical applications. Experiments: Three types of nanofibers, PCL, pNIPAM and pNIPAM/PCL were fabricated using electrospinning techniques. Their morphology and composition were characterized using SEM, IR and TGA. The drug release behaviors of these nanofibers were investigated using Franz diffusion cells and HPLC analysis. Findings: It was found that ibuprofen release rates from PLC nanofibers are not affected by the temperature in the range of 22-34 oC. In contrast, the release rates from pNIPAM nano-fibers are very sensitive to the change in temperature, which is five times higher at 22 oC compared to 34 oC. However, there is a serious burst effect at room temperature for pNIPAM nanofibers. Compared to other two types of NFs, pNIPAM core-PCL shell NFs demonstrated a much improved and controlled release at both room and higher temperature, probably due to the protection of PCL shell. Such a finding has potential applications in medical and pharmaceutical sciences for more effective disease treatments.

Keywords

PCL, pNIPAM, Core-shell nanofibers, Ibuprofen, Controlled release, Temperature responsive

Location

Concourse/Atrium

Presentation Year

2014

Start Date

11-15-2014 2:55 PM

End Date

11-15-2014 4:10 PM

Publication Type and Release Option

Presentation (Open Access)

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Nov 15th, 2:55 PM Nov 15th, 4:10 PM

Controlled Drug Release from Temperature Responsive Core-Shell Nanofibers

Concourse/Atrium

Drug delivery systems are playing an important role in the fields of medical and pharmaceutical sciences. A sustained and controlled release of drug molecules is critically important to tissue engineering and effective treatment of many diseases, ranging from arthritis to cancer therapies. In the past decade, advanced nanotechnology and nanoscience have been extensively applied to the fabrication of smart materials which can controllably release drug molecules. A common problem in drug delivery system is known as burst effect, which is most likely due to the rapid release of surface associated drug molecules. Another challenge is to realize a programmable drug delivery with variable dosing rates. Modern electrospinning technology allows for drug diffusion studies to be well controlled by tuning spinning parameters and materials. The cost, diameter, composition and structure of electrospun nanofibers can be facilely varied to regulate the drug delivery rates and kinetics. Herein, core-shell nanofibers composed of temperature-responsive core and biodegradable polymeric shell can be utilized for ‘on-demand’ and controlled drug release without burst effect for potential pharmaceutical applications. Experiments: Three types of nanofibers, PCL, pNIPAM and pNIPAM/PCL were fabricated using electrospinning techniques. Their morphology and composition were characterized using SEM, IR and TGA. The drug release behaviors of these nanofibers were investigated using Franz diffusion cells and HPLC analysis. Findings: It was found that ibuprofen release rates from PLC nanofibers are not affected by the temperature in the range of 22-34 oC. In contrast, the release rates from pNIPAM nano-fibers are very sensitive to the change in temperature, which is five times higher at 22 oC compared to 34 oC. However, there is a serious burst effect at room temperature for pNIPAM nanofibers. Compared to other two types of NFs, pNIPAM core-PCL shell NFs demonstrated a much improved and controlled release at both room and higher temperature, probably due to the protection of PCL shell. Such a finding has potential applications in medical and pharmaceutical sciences for more effective disease treatments.