Term of Award
Master of Science in Biology
Document Type and Release Option
Thesis (restricted to Georgia Southern)
Committee Member 1
Sara N. Bennett
Committee Member 2
Frank E. French
Kanamycin is an antibiotic known to inhibit protein synthesis. This study was to determine if this antibiotic when injected to pregnant females affected the development of fetuses. Virgin white mice were divided into 2 groups each with 3 subgroups. The mice in each subgroup were the same age and from the same litter when possible. Each subgroup received a 0.5cc injection, i.p., of kanamycin at one of three concentrations: 15mg/kg, SOmg/kg, and 150mg/kg. One group received injections from day 1 to 10 of gestation and the other group received injections from day 10 to birth.
Litters from the females were weighed and killed. The liver, kidneys, spleen, and adrenal glands were removed, weighed, and prepared for his tological analysis. Livers, kidneys, and spleens from all experimental subgroups demonstrated histological discrepancies differing from the same organs in control fetuses. No difference was observed between adrenal glands from experimental fetuses and control fetuses. Statistical analysis revealed that weights of the organs of the experimental and control fetuses differed significantly in only 3 subgroups of kidneys. There was, however, much variation in the weights of the experimental organs. No difference occurred in the weights of experimental fetuses and control fetuses.
Russell, Linda Kathleen, "The Effects of Kanamycin on the Development of Various Organs and Glands in White Mice" (1977). Legacy ETDs. 392.