Term of Award

Fall 2018

Degree Name

Master of Science in Applied Engineering (M.S.A.E.)

Document Type and Release Option

Thesis (restricted to Georgia Southern)

Copyright Statement / License for Reuse

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Department

Department of Mechanical Engineering

Committee Chair

Dr. Mujibur Khan

Committee Member 1

Dr.Aniruddha Mitra

Committee Member 2

Dr.Marcel Ilie

Abstract

Drug loaded polymer polycaprolactone, polyethylene glycol particles were synthesized using Emulsion-Solvent-Evaporation (ESE) process, and particle characteristics studied using SEM (Scanning Electron Microscopy), EDS and drug release tests. Ternary phase diagrams were determined for oil-water emulsion (o-w) and water-oil emulsion (w-o) for the emulsion formation and destabilization. Hydrophilic drug 5-flourouracil (5-FU), cytarabine (CTB) and hydrophobic drug ibuprofen (IBP), paclitaxel (PXT) were investigated for drug encapsulation and release analysis for a period of 9-days at pH (=7,

Research Data and Supplementary Material

No

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