Approaches Toward Novel 1,2,3-Triazole Sensors for the Detection of Anions and Heavy Metal Cations
Term of Award
Master of Science in Applied Physical Science (M.S.)
Document Type and Release Option
Thesis (open access)
Copyright Statement / License for Reuse
This work is licensed under a Creative Commons Attribution 4.0 License.
Department of Chemistry
Committee Member 1
Committee Member 2
Cations and anions play pivotal roles in biological and physiological processes, however an imbalance in concentration of any ion can be detrimental. Therefore, research into the selective recognition of anions and heavy metal cations has acquired much attention. One approach involves the use of chemosensors. Upon interaction with targeted analytes, chemosensors produce a distinct response, in some cases a fluorescent or colorimetric signal. The 1,2,3-triazole unit has much potential as a chemical sensor due to its unique photophysical properties. The specificity, selectivity, and signaling mechanism of triazole sensors can be tuned with conjugation in the motif and choice and placement of substituents in the structure. The utility of the motif is extensive with significant applications in toxicological assessments, therapeutics, and materials science. Herein we report the syntheses and analytical investigations of novel 1,2,3-triazole sensors tuned for intense color and fluorescent changes with specific analytes. Our current studies include a 1,2,3-triazole based copper (II) sensor and a dual sensor, able to detect both cations and anions. The sensors are made by copper-mediated approaches with 1) azides and alkynes in the copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC), a “click” reaction, or 2) N-tosylhydrazone and aniline substrates. Ultraviolet-Visible (UV-Vis), Fluorescence, and Nuclear Magnetic Resonance (NMR) Spectroscopy are used to investigate the selectivity and specificity of the sensors with their respective analytes.
INDEX WORDS: 1,2,3-Triazole, Chemosensor, Copper (II), Fluoride
Govan, Richard D., "Approaches Toward Novel 1,2,3-Triazole Sensors for the Detection of Anions and Heavy Metal Cations" (2017). Electronic Theses and Dissertations. 1604.
Research Data and Supplementary Material
Analytical Chemistry Commons, Organic Chemistry Commons, Other Chemistry Commons, Physical Chemistry Commons