Term of Award

Summer 2016

Degree Name

Master of Science in Applied Physical Science (M.S.)

Document Type and Release Option

Thesis (open access)

Department

Department of Chemistry

Committee Chair

Jonathan Arambula

Committee Member 1

Amanda Stewart

Committee Member 2

Worlanyo Gato

Abstract

Gold (I) coordinated N-heterocyclic carbenes containing appended redox cycling moieties were designed and analyzed for their ability to target the antioxidant network via multiple mechanisms in various human cancer cell models. Complexes containing either ferrocene or naphthoquinone redox cycling moieties were screened for inhibition of cell growth, inhibition of thioredoxin reductase (TrxR), and accentuation of exogenous ROS. The cell death pathway employed was determined by flow cytometry via detection of Annexin-V FITC. Furthermore, differential gene expression between treated cells and untreated cells revealed the induction of endoplasmic reticulum stress and unfolded protein response pathways.

Research Data and Supplementary Material

No

Included in

Biochemistry Commons

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