A Novel Biocatalytic Strategy Towards Prozac® and Other Serotonin Reuptake inhibitors, Wade Poston, Richard Hammond, Brent D. Feske
Brent Feske

Aldehydes to Lactones: A Synthetic Strategy Toward Asymmetric Lactones, Blair Weaver, Sarah Franz, Richard Watkins, Giuseppe Gumina, Brent D. Feske
Brent Feske

A Biocatalytic Approach to Synthesizing Asymmetric Lactones, Sarah Franz, Eric Branch, Richard Watkins, Giuseppe Gumina, Brent D. Feske
Brent Feske

A Novel Biocatalytic Strategy Towards Prozac® and Other Serotonin Reuptake inhibitors, Wade Poston, Richard Hammond, Brent D. Feske
Brent Feske

Alanine-Scanning Mutagenesis of the YDL124w’s Substrate Specificity Loop A, Beth Budden, Michael Page, Andre Orrego, Mande Beers, Crystal Archer, Erik Davis, Brent D. Feske
Brent Feske

A Biocatalytic Strategy Towards Chiral Lactones, Richard Watkins, Brent D. Feske
Brent Feske

An Unexpected Stereochemical Insignificance Discovered in Acinetobacter baumannii Quorum Sensing, A. Garner, S. Kim, J. Zhu, A. Struss, R. Watkins, Brent D. Feske, G. Kaufmann, K. Janda
Brent Feske

Asymmetric Reduction of β-Keto Nitriles Yielding Drug Analog Precursors for Serotonin Reuptake Inhibitors and β-Adrenergic Blocking Agents, Randall W. Nowill, Trisha J. Patel, David L. Beasley, Jose A. Alvarez, Richard Anuskiewitz, Todd J. Hizer, Brent D. Feske
Brent Feske

Aldehydes to Lactones: A Synthetic Strategy Toward Asymmetric Lactones, Blair Weaver, Sarah Franz, Richard Watkins, Giuseppe Gumina, Brent D. Feske
Brent Feske

Asymmetric Synthesis of Chiral Lactones Using Biocatalysis as the Key Step, Sarah Franz, Richard Watkins, Elizah Jackson, Mathew Goss, Giuseppe Gumina, Brent D. Feske
Brent Feske

Asymmetric Synthesis of Chiral Lactones Using Biocatalysis as the Key Step, Sarah Franz, Mathew Goss, Brent D. Feske
Brent Feske

Asymmetric Synthesis of (-)-fosfomycin and its Trans- (1S,2S)-diastereomer Using a Biocatalytic Reduction as the Key Step, C. P. Marocco, E. V. Davis, J. E. Finnell, H. Nguyen, S. C. Mateer, I. Ghiviriga, C. W. Padgett, Brent D. Feske
Brent Feske

Asymmetric Synthetic Strategy of Fosfomycin Using Biocatalysis, Brent D. Feske, Erik Davis, Christian Marocco, Julie Finnell
Brent Feske

Biocatalysis: Investigating the Reaction Profile of Promiscuous Amine Dehydrogenases, Katelyn Smith, Serina Davenport, Ariana Vargas, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Biocatalysis: Investigating the Reaction Profile of Promiscuous Amine Dehydrogenases, Katelyn Smith, Serina Davenport, Ariana Vargas, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Bestatin: Three Decades of Synthetic Strategies, Brent D. Feske
Brent Feske

Biocatalytic Reduction of a Non-Aromatic Nitro Group by a Nitroreductase from Salmonella typhimurium, Thomas Reams, Ryan Oliff, Jonathan Groover, Andreas Bommarius, Brent D. Feske
Brent Feske

Biocatalysis: Utilizing Enzymes for the Synthesis of Pharmaceuticals, Brent D. Feske
Brent Feske

Biocatalysis: Making Drugs from Bugs, Brent D. Feske, Jonathan Groover, Sarah Franz, Richard Watkins
Brent Feske

Biocatalytic Reduction of a Variety of Aromatic Nitro Compounds by Nitroreductases, Stephen Kennedy, Delia Singleton, Jonathan T. Park, Andreas Bommarius, Brent D. Feske
Brent Feske

Biocatalytic Reduction of a Non-Aromatic Nitro- Group by a Nitroreductase from Salmonella typhimurium, Thomas Reams, Ryan Oliff, Brent D. Feske
Brent Feske

Biocatalytic Reduction of a Variety of Aromatic Nitro Compounds by Nitroreductases, Stephen Kennedy, Brent D. Feske
Brent Feske

Biocatalytic Reductions of Chalcone and Chalcone Derivatives, Yanairie Caraballo, Michael C. Underwood, Sarah Zingales, Brent D. Feske
Brent Feske

Synthesis of Enamine Resistant Substrates for an Amine Dehydrogenase Library, Ariana Vargas, Staci Johnston, Phuong Nguyen, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Synthesis of Enamine Resistant Substrates for an Amine Dehydrogenase Library, Ariana Vargas, Staci Johnston, Phuong Nguyen, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Synthesis of Ethyl 2-chloro-2-methylacetoacetate: A Putative Substrate for Amine Dehydrogenase Enzymes, Ariana Vargas, Jonathan Groover, Adela Casas, Annalise Evans, Brent D. Feske
Brent Feske

Substrate Studies of Amine Dehydrogenases and the Nitroreductases, Brent D. Feske, Jonathan Groover, Thomas Reams, Jonathan Park, Bettina Bommarius, Andreas Bommarius
Brent Feske

Substrate Investigations for Amine Dehydrogenase, Annalise Evans, Jonathan Groover, Brent D. Feske, Bettina Bommarius, Andreas Bommarius
Brent Feske

Synthesis and Antimicrobial Evaluation of an Α-methylalanine Analog of Puromycin, C. Moracho, A. R. Messersmith, B. Weaver, Brent D. Feske, G. Gumina
Brent Feske

Utilizing Biocatalysis Toward Asymmetric Pharmaceuticals and Pharmaceutical Intermediates, Brent D. Feske
Brent Feske

Using Novel Amine Dehydrogenase Enzymes in the in the Asymmetric Synthesis of Amines, Adela Casas, Jonathan Groover, Abigail Sears, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Utilizing Engineered E. Coli as An Asymmetric Biocatalyst towards Pharmaceutical Precursors, Brent D. Feske
Brent Feske

Utilizing Engineered E. Coli as an Asymmetric Reducing Biocatalyst Towards Serotonin Reuptake Inhibitors, Richard Hammond, Wade Poston, Brent D. Feske
Brent Feske

Utilizing an Engineered E. Coli Library as an Asymmetric Biocatalyst Towards Pharmaceutical Precursors., Brent D. Feske, Richard Hammond, Wade Poston, Scott Mateer, Todd Hizer
Brent Feske

Utilizing Biocatalysis Toward Asymmetric Pharmaceuticals and Pharmaceutical Intermediates, Brent D. Feske
Brent Feske

Biocatalytic Synthesis Towards Both Antipodes of 3-hydroxy-3-phenylpropanitrile a Precursor to Fluoxetine, Atomoxetine and Nisoxetine, R. J. Hammond, B. W. Poston, I. Ghiviriga, Brent D. Feske
Brent Feske

Biocatalytic Reductions of Chalcone and Chalcone Derivatives, Yanairie Caraballo, Michael Underwood, Brent D. Feske
Brent Feske

Biocatalytic Strategy Towards Asymmetric β- Hydroxy Nitriles and γ-Amino Alcohols, R. W. Nowill, T. J. Patel, D. L. Beasley, J. Alvarez, E. Jackson III, T. J. Hizer, I. Ghiviriga, S. C. Mateer, Brent D. Feske
Brent Feske

Bioengineering – Using Nature’s Catalysts in Drug Development, Brent D. Feske, G. Shields
Brent Feske

Biocatalytic, Stereoselective Reduction of 4-Chlorobenzoylacetonitrile Using a Reductase Library, Elizah Jackson, Brent D. Feske
Brent Feske

Biocatalytic, Stereoselective Reduction of 4-Chlorobenzoylacetonitrile Using a Reductase Library, Elizah Jackson, Brent D. Feske
Brent Feske

Characterizing the Substrate Binding Specificity of an Aldo-Keto Reductase YDL124w, Faye Montgomery, Beth Budden, Mande Beers, Michael Page, Andrea Orrego, Erik Davis, Brent D. Feske
Brent Feske

Demonstrating Rational Drug Design Using Free Docking Software, Mitch Weiland, Elizabeth Bartholomew, Stephen Savioli, Brent D. Feske, Clifford W. Padgett
Brent Feske

Characterizing Substrate Specificity in the Aldo-Keto Reductase, YDL124w, Madelyn Roush, Brandon Stevenson, Cassandra Connolly, Candace Poole, Clifford Padgett, Brent D. Feske, Scott Mateer
Brent Feske

Chiral Lactones, Eric Branch, Sarah Franz, Richard Watkins, Brent D. Feske
Brent Feske

Design, Synthesis, and Antimicrobial Evaluation of a Novel 3’-c-acetohydrazide Puromycin Analog, J. Carter, B. Weaver, M. Chiacchio, A. R. Messersmith, Brent D. Feske, G. Gumina
Brent Feske

Characterizing Substrate-Specificity in the Aldo-Keto Reductase, Ydl124w via Modified Alanine-Scanning Mutagenesis, Jamie Hall, Brandon Stevenson, Candace Poole, Brent D. Feske, Scott C. Mateer
Brent Feske

Exploring the Chlorination of Diethyl cyanophosphonate, Ashlynn Dykes, Todd Hizer, Brent D. Feske
Brent Feske

Enantiodivergent, Biocatalytic Routes to Both Taxol Side Chain Antipodes, Brent D. Feske, I. A. Kaluzna, J. D. Stewart
Brent Feske

Divergent Synthesis of Novel 3-α- and 3-β-c-functionalized Ribose Derivatives, J. Carter, B. Weaver, M. Chiacchio, W. E. Lynch, Brent D. Feske, G. Gumina
Brent Feske

Exploring Biocatalytic Chalcone Reductions Using a Library of Ketoreductases, Michael Underwood, Yanairie Caraballo, Sarah Zingales, Brent D. Feske
Brent Feske

Chemoenzymatic Formal Total Synthesis of (-)-Bestatin, Brent D. Feske, J. D. Stewart
Brent Feske

Difluorination of (2-Nitoethyl)benzene for Enzymatic Purposes, Delia Singleton, Brent D. Feske
Brent Feske

Enantioselectivity and Enzyme- Substrate Docking Studies of a Ketoreductase from Sporobolomyces salmonicolor (SSCR) and Saccharomyces cerevisiae (YOL151w), P. Nguyen, M. West, Brent D. Feske, C. W. Padgett
Brent Feske

Demonstrating Rational Drug Design Using Free Docking Software, E. A. Bartholomew, S. J. Savioli, M. M. West, Brent D. Feske, M. H. Weiland, C. W. Padgett
Brent Feske

Green Chemistry Synthesis of γ-phenyl-γ-butyrolactone Using a Whole-cell Biocatalytic Approach, Jack Benton, David Beasley, Brent D. Feske
Brent Feske

Instrumental Analysis: A Research Experiment Designing An Instrumental Analysis Course around Student Research Projects, Katie Verges, Brent D. Feske, Will Lynch, Clifford Padgett, Delana Nivens
Brent Feske

Investigating and Expanding the Biocatalytic Capabilities of Amine Dehydrogenase, Katelyn Smith, Serina Davenport, Ariana Vargas, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Investigation of Novel Amine Dehydrogenases for the Asymmetric Synthesis of Amines, Jonathan Groover, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Green Chemistry: Reduction of β-Keto Nitriles Using Bioengineered E. Coli, Jose Alvarez, Richard Anusckiewitz, Kira Isengard, Brent D. Feske
Brent Feske

Improving Asymmetric Reductions by Building Reductase Chimeras and the Investigation of Reductase Mutagenesis, Crystal Archer, Erik Davis, Ruchita Patel, Mande Beers, Scott Mateer, Brent D. Feske
Brent Feske

Faculty and K-12 Teacher Development for the Improvement of STEM Education, Brent D. Feske, Ardyth Foster
Brent Feske

Identification of Residues that Specify Substrate Binding in the Aldo-Keto Reductase, YDL124w, Cassandra Connelly, Maddy Roush, Beth Budden, Andrea Orrego, Mike Page, Brandon Stevenson, Brent D. Feske
Brent Feske

Making Drugs with Little Bugs, Brent D. Feske, Scott C. Mateer
Brent Feske

Synthetic Strategy toward γ-Keto Nitriles and Their Biocatalytic Conversion to Asymmetric γ-Lactones, S. E. Franz, R. R. Watkins, L. A. Wright, B. A. Weaver, R. C. Hartage, I. Ghiviriga, G. Gumina, Brent D. Feske
Brent Feske

Using Biocatalysis to Integrate Organic Chemistry into a Molecular Biology Laboratory Course, M. Beers, C. Archer, Brent D. Feske, S. C. Mateer
Brent Feske

Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases, S. K. Au, J. Groover, Brent D. Feske, A. S. Bommarius
Brent Feske

Synthesis, Stereochemical Characterization, and Antimicrobial Evaluation of a Potential Non-Nephrotoxic 3'-c-acethydrazide Puromycin Analog, J. Carter, B. A. Weaver, M. A. Chiacchio, A. R. Messersmith, W. E. Lynch, Brent D. Feske, G. Gumina
Brent Feske

Synthetic Studies Toward 3’-C-puromycin Analogs, G. Gumina, C. Moracho, Brent D. Feske
Brent Feske

Stereoselective, Biocatalytic Reductions of α-chloro-β-keto Esters, I. A. Kaluzna, Brent D. Feske, W. Wittayanan, I. Ghiviriga, J. D. Stewart
Brent Feske

Mutagenic Analysis of Reductase Stereoselectivity, Beth Budden, Michael Page, Andrea Orrego, Mande Beers, Crystal Archer, Eric Davis, Brent D. Feske
Brent Feske

Mutagenesis of the Yeast Reductase Gene, YDL124w, Beth Budden, Faye Montgomery, Madelyn Roush, Michael Page, Andrea Orrego, Mande Beers, Brent D. Feske
Brent Feske

Mutagenesis of the Yeast Reductase Gene, YDL124w, Beth Budden, Michael Page, Andrea Orrego, Mande Beers, Crystal Archer, Eric Davis, Brent D. Feske
Brent Feske

Mutagenic Analysis of Reductase Stereoselectivity, Scott C. Mateer, Brent D. Feske, A. Orrego, Beth Budden, M. Page, M. Beers, A. Archer
Brent Feske

Optimization of Reaction Conditions for an Amine Dehydrogenase Reaction, Adela Casas, Jonathan Groover, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Optimization of Reaction Conditions for an Amine Dehydrogenase Reaction and New Substrate Synthesis, Adela Casas, Annalise Evans, Jonathan Groover, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Recent Investigations of Amine Dehydrogenases and Nitroreductases, Brent D. Feske, Adela Casas, Jonathan Groover, Thomas Reams, Jonathan Park, Bettina Bommarius, Andreas Bommarius
Brent Feske

Production of Chiral Amines Using Enamine Resistant Substrates, Ariana Vargas, Staci Johnston, Phuong Nguyen, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Optimization of Reaction Conditions of Amination by Amine Dehydrogenase Enzymes, Jonathan Groover, Adela Casas, Bettina Bommarius, Andreas Bommarius, Brent D. Feske
Brent Feske

Production of Chiral Amines Using Enamine Resistant Substrates, Staci Johnston, Ariana Vargas, Brent D. Feske
Brent Feske

Stereochemical Predictions of Aldo-Keto Reductase Products through Molecular Modeling, John E. Walker, John Knudsen, Stephen Savioli, Brent D. Feske, Scott Mateer, Clifford W. Padgett
Brent Feske

Stereochemical Predictions of the Products from a Carbonyl Reductase from Sporobolomyces Salmonicolor through Docking and Molecular Dynamics, Phung-Hoang Nguyen, Brent D. Feske, Scott Mateer, Clifford Padgett
Brent Feske

Structure Prediction Using a Homology Model of YOL151w, Phung-Hoang T. Nguyen, Maya West, Scott C. Mateer, Brent D. Feske, Clifford W. Padgett
Brent Feske

Stereoselective Reduction of β-Keto Nitriles Using a Reductase Library, Randall Nowill, Trisha Patel, David Beasley, Jose Alvarez, Elizah Beasley, Brent D. Feske
Brent Feske

Targeted Mutation of the Yeast Reductase, YDL 124w, Affects Enzyme Stereoselectivity, Crystal Archer, Erik Davis, Ruchita Patel, Mande Beers, Scott C. Mateer, Brent D. Feske
Brent Feske

Synthetic Studies Toward Metabolically Stable Puromycin Analogs, G. Gumina, A. R. Messersmith, D. H. Eagerton, Brent D. Feske
Brent Feske

Using Biocatalysis to Produce Chiral, Biologically Active Lactones, Richard Watkins, Ryan Oliff, Sarah Franz, Blair Weaver, Giuseppe Gumina, Brent D. Feske
Brent Feske

Using Biocatalysis to Produce Chiral, Biologically Active Lactones, Ryan Oliff, Richard Watkins, Sarah Franz, Blair Weaver, Giuseppe Gumina, Brent D. Feske
Brent Feske

Targeted Mutation of the Yeast Reductase, YDL124w, Crystal Archer, Erik Davis, Ruchita Patel, Mande Beers, Scott C. Mateer, Brent D. Feske
Brent Feske

Substrate Investigation of Amine Dehydrogenase and the Nitroreductase NRSal, Brent D. Feske, Jonathan Groover, Thomas Reams, Jonathan Park, Bettina Bommarius, Andreas Bommarius
Brent Feske

Synthesis of Pharmaceutical Precursors Using Biocatalysis, Brent D. Feske
Brent Feske

Synthesis of Substrates for Chiral Amine Production, Staci Johnston, Alex Merritt, Brent D. Feske
Brent Feske

Structure Prediction Using a Homology Model of YOL151w, Phung-Hoang Nguyen, Clifford W. Padgett, Brent D. Feske, Scott C. Mateer
Brent Feske

Synthesis of Fosfomycin Utilizing Biocatalysis as a Key Step, Brent D. Feske, Erik V. Davis
Brent Feske

Substrate Development of Substrates for Amine Dehydrogenases, Staci Johnston, Ariana Vargas, Brent D. Feske, Bettina Bommarius, Andreas Bommarius
Brent Feske

Synthesis of Fosfomycin Using Whole-Cell Biocatalysis as the Key Step, Christian Marocco, Erik Davis, Julie Finnell, Brent D. Feske
Brent Feske

Synthesis of Fluorinated Substrate Analogs for Nitroreductase Enzymes, Delia Singleton, Thomas Reams, Brent D. Feske
Brent Feske

Synthesis of Fosfomycin Using Whole-Cell Biocatalysis as the Key Step, Christian Marocco, Erik Davis, Julie Finnell, Brent D. Feske
Brent Feske

Synthesis of a Natural Product Caerulomycin Derivative, Blair Weaver, Jonathan Groover, Gary Guillet, Brent D. Feske
Brent Feske

New Mass Spectrometer will Advance Teaching, Research, and Collaborations in Southeast Georgia, Brent D. Feske, G. Shields
Brent Feske

Synthesis of γ-Ketonitriles and Their Enzymatic Enantioselective Reduction, Laura Wright, Guiseppe Gumina, Brent D. Feske
Brent Feske

Synthesis of γ-Keto Nitriles and a Biocatalytic Approach to Asymmetric Lactones, Richard Watkins, Brent D. Feske
Brent Feske

Synthesis of a Natural Product Derivative, Blair Weaver, Brent D. Feske
Brent Feske

Synthetic Strategy Toward β-Keto Alkynes, Brent D. Feske, Sarah Zingales, Michael C. Underwood
Brent Feske

Synthesis of γ-Keto Nitriles and a Biocatalytic Approach to Asymmetric Lactones, Richard Watkins, Sarah Franz, Elizah Jackson, Mathew Goss, Giuseppe Gumina, Brent D. Feske
Brent Feske

Biocatalytic Reductions of Chalcone and Chalcone Derivatives, Yanairie Caraballo, Michael C. Underwood, Sarah Zingales, Brent D. Feske
Sarah Zingales

Exploring Biocatalytic Chalcone Reductions Using a Library of Ketoreductases, Michael Underwood, Yanairie Caraballo, Sarah Zingales, Brent D. Feske
Sarah Zingales

Synthetic Strategy Toward β-Keto Alkynes, Brent D. Feske, Sarah Zingales, Michael C. Underwood
Sarah Zingales

Synthesis of Enamine Resistant Substrates for an Amine Dehydrogenase Library, Ariana Vargas, Staci Johnston, Phuong Nguyen, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalysis: Investigating the Reaction Profile of Promiscuous Amine Dehydrogenases, Katelyn Smith, Serina Davenport, Ariana Vargas, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of Enamine Resistant Substrates for an Amine Dehydrogenase Library, Ariana Vargas, Staci Johnston, Phuong Nguyen, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalysis: Investigating the Reaction Profile of Promiscuous Amine Dehydrogenases, Katelyn Smith, Serina Davenport, Ariana Vargas, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalysis: Making Drugs from Bugs, Brent D. Feske, Jonathan Groover, Sarah Franz, Richard Watkins
Department of Chemistry and Biochemistry Faculty Presentations

Production of Chiral Amines Using Enamine Resistant Substrates, Ariana Vargas, Staci Johnston, Phuong Nguyen, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Investigating and Expanding the Biocatalytic Capabilities of Amine Dehydrogenase, Katelyn Smith, Serina Davenport, Ariana Vargas, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Faculty and K-12 Teacher Development for the Improvement of STEM Education, Brent D. Feske, Ardyth Foster
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis, Stereochemical Characterization, and Antimicrobial Evaluation of a Potential Non-Nephrotoxic 3'-c-acethydrazide Puromycin Analog, Josh Carter, Blair A. Weaver, Maria A. Chiacchio, Amy R. Messersmith, Will E. Lynch, Brent D. Feske, Giuseppe Gumina
Department of Chemistry and Biochemistry Faculty Publications

Production of Chiral Amines Using Enamine Resistant Substrates, Staci Johnston, Ariana Vargas, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthetic Strategy Toward β-Keto Alkynes, Brent D. Feske, Sarah Zingales, Michael C. Underwood
Department of Chemistry and Biochemistry Faculty Presentations

Synthetic Studies Toward 3’-C-puromycin Analogs, Giuseppe Gumina, Carolina Moracho, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Publications

Substrate Development of Substrates for Amine Dehydrogenases, Staci Johnston, Ariana Vargas, Brent D. Feske, Bettina R. Bommarius, Andreas S. Bommarius
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of Substrates for Chiral Amine Production, Staci Johnston, Alex Merritt, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of Ethyl 2-chloro-2-methylacetoacetate: A Putative Substrate for Amine Dehydrogenase Enzymes, Ariana Vargas, Jonathan Groover, Adela Casas, Annalise Evans, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthetic Studies Toward Metabolically Stable Puromycin Analogs, G. Gumina, A. R. Messersmith, D. H. Eagerton, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis and Antimicrobial Evaluation of an Α-methylalanine Analog of Puromycin, C. Moracho, A. R. Messersmith, B. Weaver, Brent D. Feske, G. Gumina
Department of Chemistry and Biochemistry Faculty Presentations

Divergent Synthesis of Novel 3-α- and 3-β-c-functionalized Ribose Derivatives, Josh Carter, Blair A. Weaver, Maria A. Chiacchio, Will E. Lynch, Brent D. Feske, Giuseppe Gumina
Department of Chemistry and Biochemistry Faculty Presentations

Design, Synthesis, and Antimicrobial Evaluation of a Novel 3’-c-acetohydrazide Puromycin Analog, Josh A. Carter, Blair A. Weaver, Maria A. Chiacchio, Amy R. Messersmith, Brent D. Feske, Giuseppe Gumina
Department of Chemistry and Biochemistry Faculty Presentations

Substrate Investigations for Amine Dehydrogenase, Annalise Evans, Jonathan Groover, Brent D. Feske, Bettina R. Bommarius, Andreas S. Bommarius
Department of Chemistry and Biochemistry Faculty Presentations

Chapter 7 - Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases, Samantha K. Au, Jonathan Groover, Brent D. Feske, Andreas S. Bommarius
Department of Chemistry and Biochemistry Faculty Publications

Synthesis of a Natural Product Derivative, Blair Weaver, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Optimization of Reaction Conditions for an Amine Dehydrogenase Reaction and New Substrate Synthesis, Adela Casas, Annalise Evans, Jonathan Groover, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Reductions of Chalcone and Chalcone Derivatives, Yanairie Caraballo, Michael Underwood, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Reduction of a Variety of Aromatic Nitro Compounds by Nitroreductases, Stephen Kennedy, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Recent Investigations of Amine Dehydrogenases and Nitroreductases, Brent D. Feske, Adela Casas, Jonathan Groover, Thomas Reams, Jonathan Park, Bettina R. Bommarius, Andreas S. Bommarius
Department of Chemistry and Biochemistry Faculty Presentations

Exploring Biocatalytic Chalcone Reductions Using a Library of Ketoreductases, Michael Underwood, Yanairie Caraballo, Sarah Zingales, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Reductions of Chalcone and Chalcone Derivatives, Yanairie Caraballo, Michael C. Underwood, Sarah Zingales, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Substrate Studies of Amine Dehydrogenases and the Nitroreductases, Brent D. Feske, Jonathan Groover, Thomas Reams, Jonathan Park, Bettina R. Bommarius, Andreas S. Bommarius
Department of Chemistry and Biochemistry Faculty Presentations

Utilizing Biocatalysis Toward Asymmetric Pharmaceuticals and Pharmaceutical Intermediates, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of Pharmaceutical Precursors Using Biocatalysis, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Using Novel Amine Dehydrogenase Enzymes in the in the Asymmetric Synthesis of Amines, Adela Casas, Jonathan Groover, Abigail Sears, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of a Natural Product Caerulomycin Derivative, Blair Weaver, Jonathan Groover, Gary Guillet, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Optimization of Reaction Conditions for an Amine Dehydrogenase Reaction, Adela Casas, Jonathan Groover, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Reduction of a Variety of Aromatic Nitro Compounds by Nitroreductases, Stephen Kennedy, Delia Singleton, Jonathan T. Park, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Reduction of a Non-Aromatic Nitro- Group by a Nitroreductase from Salmonella typhimurium, Thomas Reams, Ryan Oliff, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Enantioselectivity and Enzyme- Substrate Docking Studies of a Ketoreductase from Sporobolomyces salmonicolor (SSCR) and Saccharomyces cerevisiae (YOL151w), P. Nguyen, M. West, Brent D. Feske, Clifford W. Padgett
Department of Chemistry and Biochemistry Faculty Publications

Optimization of Reaction Conditions of Amination by Amine Dehydrogenase Enzymes, Jonathan Groover, Adela Casas, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Difluorination of (2-Nitoethyl)benzene for Enzymatic Purposes, Delia Singleton, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of Fluorinated Substrate Analogs for Nitroreductase Enzymes, Delia Singleton, Thomas Reams, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Substrate Investigation of Amine Dehydrogenase and the Nitroreductase NRSal, Brent D. Feske, Jonathan Groover, Thomas Reams, Jonathan Park, Bettina R. Bommarius, Andreas S. Bommarius
Department of Chemistry and Biochemistry Faculty Presentations

Synthetic Strategy toward γ-Keto Nitriles and Their Biocatalytic Conversion to Asymmetric γ-Lactones, Sarah E. Franz, Richard R. Watkins, Laura A. Wright, Blair A. Weaver, Ramon C. Hartage, Ion Ghiviriga, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Publications

Demonstrating Rational Drug Design Using Free Docking Software, Elizabeth A. Bartholomew, Stephen J. Savioli, Maya M. West, Brent D. Feske, Mitch H. Weiland, Clifford W. Padgett
Department of Chemistry and Biochemistry Faculty Publications

Investigation of Novel Amine Dehydrogenases for the Asymmetric Synthesis of Amines, Jonathan Groover, Bettina R. Bommarius, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Exploring the Chlorination of Diethyl cyanophosphonate, Ashlynn Dykes, Todd J. Hizer, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Aldehydes to Lactones: A Synthetic Strategy Toward Asymmetric Lactones, Blair Weaver, Sarah Franz, Richard Watkins, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Using Biocatalysis to Produce Chiral, Biologically Active Lactones, Ryan Oliff, Richard Watkins, Sarah Franz, Blair Weaver, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Chiral Lactones, Eric Branch, Sarah Franz, Richard Watkins, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Reduction of a Non-Aromatic Nitro Group by a Nitroreductase from Salmonella typhimurium, Thomas Reams, Ryan Oliff, Jonathan Groover, Andreas S. Bommarius, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

A Biocatalytic Strategy Towards Chiral Lactones, Richard Watkins, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Utilizing Biocatalysis Toward Asymmetric Pharmaceuticals and Pharmaceutical Intermediates, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalysis: Utilizing Enzymes for the Synthesis of Pharmaceuticals, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Using Biocatalysis to Integrate Organic Chemistry into a Molecular Biology Laboratory Course, Mande Beers, Crystal Archer, Brent D. Feske, Scott C. Mateer
Department of Chemistry and Biochemistry Faculty Publications

An Unexpected Stereochemical Insignificance Discovered in Acinetobacter baumannii Quorum Sensing, Amanda L. Garner, Sook Kyung Kim, Jie Zhu, Anjali Kumari Struss, Richard Watkins, Brent D. Feske, Gunnar F. Kaufmann, Kim D. Janda
Department of Chemistry and Biochemistry Faculty Publications

Using Biocatalysis to Produce Chiral, Biologically Active Lactones, Richard Watkins, Ryan Oliff, Sarah Franz, Blair Weaver, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Demonstrating Rational Drug Design Using Free Docking Software, Mitch Weiland, Elizabeth Bartholomew, Stephen Savioli, Brent D. Feske, Clifford W. Padgett
Department of Chemistry and Biochemistry Faculty Presentations

Characterizing Substrate-Specificity in the Aldo-Keto Reductase, Ydl124w via Modified Alanine-Scanning Mutagenesis, Jamie Hall, Brandon Stevenson, Candace Poole, Brent D. Feske, Scott C. Mateer
Department of Chemistry and Biochemistry Faculty Presentations

Asymmetric Synthesis of Chiral Lactones Using Biocatalysis as the Key Step, Sarah Franz, Richard Watkins, Elizah Jackson, Mathew Goss, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Asymmetric Synthesis of Chiral Lactones Using Biocatalysis as the Key Step, Sarah Franz, Mathew Goss, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Aldehydes to Lactones: A Synthetic Strategy Toward Asymmetric Lactones, Blair Weaver, Sarah Franz, Richard Watkins, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of γ-Keto Nitriles and a Biocatalytic Approach to Asymmetric Lactones, Richard Watkins, Sarah Franz, Elizah Jackson, Mathew Goss, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of γ-Keto Nitriles and a Biocatalytic Approach to Asymmetric Lactones, Richard Watkins, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Structure Prediction Using a Homology Model of YOL151w, Phung-Hoang Nguyen, Clifford W. Padgett, Brent D. Feske, Scott C. Mateer
Department of Chemistry and Biochemistry Faculty Presentations

Structure Prediction Using a Homology Model of YOL151w, Phung-Hoang T. Nguyen, Maya West, Scott C. Mateer, Brent D. Feske, Clifford W. Padgett
Department of Chemistry and Biochemistry Faculty Presentations

Identification of Residues that Specify Substrate Binding in the Aldo-Keto Reductase, YDL124w, Cassandra Connelly, Maddy Roush, Beth Budden, Andrea Orrego, Mike Page, Brandon Stevenson, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Characterizing Substrate Specificity in the Aldo-Keto Reductase, YDL124w, Madelyn Roush, Brandon Stevenson, Cassandra Connolly, Candace Poole, Clifford W. Padgett, Brent D. Feske, Scott Mateer
Department of Chemistry and Biochemistry Faculty Presentations

A Biocatalytic Approach to Synthesizing Asymmetric Lactones, Sarah Franz, Eric Branch, Richard Watkins, Giuseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Strategy Towards Asymmetric β- Hydroxy Nitriles and γ-Amino Alcohols, Randall W. Nowill, Trisha J. Patel, David L. Beasley, Jose A. Alvarez, Elizah Jackson III, Todd J. Hizer, Ion Ghiviriga, Scott C. Mateer, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Publications

Synthesis of Fosfomycin Using Whole-Cell Biocatalysis as the Key Step, Christian P. Marocco, Erik V. Davis, Julie E. Finnell, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of Fosfomycin Using Whole-Cell Biocatalysis as the Key Step, Christian P. Marocco, Erik V. Davis, Julie E. Finnell, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic, Stereoselective Reduction of 4-Chlorobenzoylacetonitrile Using a Reductase Library, Elizah Jackson, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Asymmetric Synthesis of (-)-fosfomycin and its Trans- (1S,2S)-diastereomer Using a Biocatalytic Reduction as the Key Step, Christian P. Marocco, Erik V. Davis, Julie E. Finnell, Phung-Hoang Nguyen, Scott C. Mateer, Ion Ghiviriga, Clifford W. Padgett, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Publications

Synthesis of γ-Ketonitriles and Their Enzymatic Enantioselective Reduction, Laura Wright, Guiseppe Gumina, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Stereoselective Reduction of β-Keto Nitriles Using a Reductase Library, Randall Nowill, Trisha Patel, David Beasley, Jose Alvarez, Elizah Beasley, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Stereochemical Predictions of the Products from a Carbonyl Reductase from Sporobolomyces Salmonicolor through Docking and Molecular Dynamics, Phung-Hoang Nguyen, Brent D. Feske, Scott Mateer, Clifford W. Padgett
Department of Chemistry and Biochemistry Faculty Presentations

Characterizing the Substrate Binding Specificity of an Aldo-Keto Reductase YDL124w, Faye Montgomery, Beth Budden, Mande Beers, Michael Page, Andrea Orrego, Erik Davis, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic, Stereoselective Reduction of 4-Chlorobenzoylacetonitrile Using a Reductase Library, Elizah Jackson, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Asymmetric Synthetic Strategy of Fosfomycin Using Biocatalysis, Brent D. Feske, Erik V. Davis, Christian P. Marocco, Julie E. Finnell
Department of Chemistry and Biochemistry Faculty Presentations

Asymmetric Reduction of β-Keto Nitriles Yielding Drug Analog Precursors for Serotonin Reuptake Inhibitors and β-Adrenergic Blocking Agents, Randall W. Nowill, Trisha J. Patel, David L. Beasley, Jose A. Alvarez, Richard Anuskiewitz, Todd J. Hizer, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Mutagenic Analysis of Reductase Stereoselectivity, Scott C. Mateer, Brent D. Feske, A. Orrego, Beth Budden, M. Page, M. Beers, A. Archer
Department of Chemistry and Biochemistry Faculty Presentations

Mutagenesis of the Yeast Reductase Gene, YDL124w, Beth Budden, Faye Montgomery, Madelyn Roush, Michael Page, Andrea Orrego, Mande Beers, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

New Mass Spectrometer will Advance Teaching, Research, and Collaborations in Southeast Georgia, Brent D. Feske, G. Shields
Department of Chemistry and Biochemistry Faculty Publications

Bioengineering – Using Nature’s Catalysts in Drug Development, Brent D. Feske, G. Shields
Department of Chemistry and Biochemistry Faculty Publications

Utilizing Engineered E. Coli as An Asymmetric Biocatalyst towards Pharmaceutical Precursors, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Instrumental Analysis: A Research Experiment Designing An Instrumental Analysis Course around Student Research Projects, Katie Verges, Brent D. Feske, Will E. Lynch, Clifford W. Padgett, Delana A. Gajdosik-Nivens
Department of Chemistry and Biochemistry Faculty Presentations

Alanine-Scanning Mutagenesis of the YDL124w’s Substrate Specificity Loop A, Beth Budden, Michael Page, Andre Orrego, Mande Beers, Crystal Archer, Erik Davis, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Synthesis of Fosfomycin Utilizing Biocatalysis as a Key Step, Brent D. Feske, Erik V. Davis
Department of Chemistry and Biochemistry Faculty Presentations

Stereochemical Predictions of Aldo-Keto Reductase Products through Molecular Modeling, John E. Walker, John Knudsen, Stephen Savioli, Brent D. Feske, Scott Mateer, Clifford W. Padgett
Department of Chemistry and Biochemistry Faculty Presentations

Mutagenic Analysis of Reductase Stereoselectivity, Beth Budden, Michael Page, Andrea Orrego, Mande Beers, Crystal Archer, Eric Davis, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Mutagenesis of the Yeast Reductase Gene, YDL124w, Beth Budden, Michael Page, Andrea Orrego, Mande Beers, Crystal Archer, Eric Davis, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Targeted Mutation of the Yeast Reductase, YDL 124w, Affects Enzyme Stereoselectivity, Crystal Archer, Erik Davis, Ruchita Patel, Mande Beers, Scott C. Mateer, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Green Chemistry: Reduction of β-Keto Nitriles Using Bioengineered E. Coli, Jose Alvarez, Richard Anusckiewitz, Kira Isengard, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Making Drugs with Little Bugs, Brent D. Feske, Scott C. Mateer
Department of Chemistry and Biochemistry Faculty Presentations

Bestatin: Three Decades of Synthetic Strategies, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Publications

Utilizing Engineered E. Coli as an Asymmetric Reducing Biocatalyst Towards Serotonin Reuptake Inhibitors, Richard J. Hammond, Benjamin W. Poston, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Utilizing an Engineered E. Coli Library as an Asymmetric Biocatalyst Towards Pharmaceutical Precursors., Brent D. Feske, Richard J. Hammond, Benjamin W. Poston, Scott C. Mateer, Todd J. Hizer
Department of Chemistry and Biochemistry Faculty Presentations

Green Chemistry Synthesis of γ-phenyl-γ-butyrolactone Using a Whole-cell Biocatalytic Approach, Jack Benton, David Beasley, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

A Novel Biocatalytic Strategy Towards Prozac® and Other Serotonin Reuptake inhibitors, Benjamin W. Poston, Richard J. Hammond, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

A Novel Biocatalytic Strategy Towards Prozac® and Other Serotonin Reuptake inhibitors, Benjamin W. Poston, Richard J. Hammond, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Targeted Mutation of the Yeast Reductase, YDL124w, Crystal Archer, Erik Davis, Ruchita Patel, Mande Beers, Scott C. Mateer, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Improving Asymmetric Reductions by Building Reductase Chimeras and the Investigation of Reductase Mutagenesis, Crystal Archer, Erik Davis, Ruchita Patel, Mande Beers, Scott Mateer, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Presentations

Biocatalytic Synthesis Towards Both Antipodes of 3-hydroxy-3-phenylpropanitrile a Precursor to Fluoxetine, Atomoxetine and Nisoxetine, Richard J. Hammond, Benjamin W. Poston, Ion Ghiviriga, Brent D. Feske
Department of Chemistry and Biochemistry Faculty Publications

Enantiodivergent, Biocatalytic Routes to Both Taxol Side Chain Antipodes, Brent D. Feske, Iwona A. Kaluzna, Jon D. Stewart
Department of Chemistry and Biochemistry Faculty Publications

Chemoenzymatic Formal Total Synthesis of (-)-Bestatin, Brent D. Feske, Jon D. Stewart
Department of Chemistry and Biochemistry Faculty Publications

Stereoselective, Biocatalytic Reductions of α-chloro-β-keto Esters, Iwona A. Kaluzna, Brent D. Feske, Weerawut Wittayanan, Ion Ghiviriga, Jon D. Stewart
Department of Chemistry and Biochemistry Faculty Publications

Stereoselective, Biocatalytic Reductions of α-chloro-β-keto Esters, Iwona A. Kaluzna, Brent D. Feske, Weerawut Wittayanan, Ion Ghiviriga, Jon D. Stewart
Brent Feske