Time-to-Event Endpoint Methods in Antibiotic Trials
Contribution to Book
Design and Analysis of Clinical Trials with Time-to-Event Endpoints
Two efﬁcacy endpoints of primary interest in the clinical development of antibiotic drugs for the treatment of infections are microbiological cure and clinical cure. Microbiological cure is typically deﬁned as eradication of the infecting pathogen by the end of treatment and at the posttreatment follow-up visit. Similarly, clinical cure is deﬁned as complete abatement of signs and symptoms of the infection by the end of treatment and at the posttreatment follow-up visit.
Peace, Karl E..
"Time-to-Event Endpoint Methods in Antibiotic Trials."
Design and Analysis of Clinical Trials with Time-to-Event Endpoints (1st Edition), Karl E. Peace (Ed.): Chapman and Hall/CRC Press.