Statistical Considerations for Clinical Trials During COVID-19: Impacts on Permuted Block Randomization and Mitigations
Randomization is the foundation of any randomized controlled trial involving treatment comparisons. The major benefits of randomization in the context of clinical trials are:
- Randomization helps mitigate various experimental biases.
- It promotes comparability of treatment groups with respect to important known and unknown prognostic factors that may be correlated with the primary outcome.
- It is the basis for the validity of standard statistical tests and makes the underlying assumptions of random sampling more plausible.
- It can form the basis for statistical inference through re-randomization tests.
Liu, Qing, Karl E. Peace.
"Statistical Considerations for Clinical Trials During COVID-19: Impacts on Permuted Block Randomization and Mitigations."