Cluster Analysis of Urinary Tobacco Biomarkers among U.S. Adults: Population Assessment of Tobacco and Health (PATH) Biomarker Study (2013-2014).”
Presentation given at 7th Annual Conference. Complementary Contributions of Tobacco Control and Regulatory Science Research to Protecting the Public Health.
Background: Urinary biomarkers of exposures (BOE) to nicotine, Tobacco-Specific Nitrosamines (TSNA), Volatile Organic Compounds (VOC), and Polycyclic Aromatic Hydrocarbons (PAH) offer objective measurement of toxicant exposure. We used cluster analysis to identify and describe data-driven groups (clusters) of tobacco users, based on concentrations of urinary tobacco biomarkers. Methods: Data are from Wave 1 of the PATH Study (2013-2014). The study included established current tobacco users, who had complete data on biomarkers of nicotine (TNE2), TSNA (NNN and NNAL), VOC (CYMA, CEMA, and MHB3), and PAH (1-NAP and 3-FLUO) (N=6,724). Adults were classified into smokers/users of: combustible cigarettes only; ecigarettes only; other combustible tobacco (OCT; cigars, pipe, and hookah) only; smokeless tobacco (SLT) only; dual users; and poly users. Cluster analysis and multivariable multinomial logistic regression were used. Results: Half the sample were exclusive cigarette smokers; 32.3% were poly users; 5.2% were SLT users; and 4.2% were dual users. Based on concentrations of BOE, nine clusters were identified and cluster membership varied by pattern of use. Of adults who smoked cigarettes only, 37.6% were in cluster I (slightly high TNE2 and TSNA and somewhat high PAH and VOC) and 24% belonged to II (somewhat low TNE2, TSNA, PAH, and VOC). Third of exclusive e-cigarette users belonged to cluster VI (high TNE2 and very high TSNA, and low/very low PAH and VOC). Conclusions: Findings suggest that level of exposure to tobacco toxicants among users vary by type and number of product used, and provide some evidence for nicotine product continuum of risk.
7th Annual Conference. Complementary Contributions of Tobacco Control and Regulatory Science Research to Protecting the Public Health
Majeed, Ban, Daniel F. Linder, Yelena Tarasenko, Danielle Smith, Yutao Liu, Thomas Eissenberg, David L. Ashley.
"Cluster Analysis of Urinary Tobacco Biomarkers among U.S. Adults: Population Assessment of Tobacco and Health (PATH) Biomarker Study (2013-2014).”."
Biostatistics, Epidemiology, and Environmental Health Sciences Faculty Presentations.