Term of Award

1977

Degree Name

Master of Science in Biology

Document Type and Release Option

Thesis (restricted to Georgia Southern)

Department

Department of Biology

Committee Chair

Sturgis McKeever

Committee Member 1

Sara N. Bennett

Committee Member 2

Frank E. French

Abstract

Kanamycin is an antibiotic known to inhibit protein synthesis. This study was to determine if this antibiotic when injected to pregnant females affected the development of fetuses. Virgin white mice were divided into 2 groups each with 3 subgroups. The mice in each subgroup were the same age and from the same litter when possible. Each subgroup received a 0.5cc injection, i.p., of kanamycin at one of three concentrations: 15mg/kg, SOmg/kg, and 150mg/kg. One group received injections from day 1 to 10 of gestation and the other group received injections from day 10 to birth.

Litters from the females were weighed and killed. The liver, kidneys, spleen, and adrenal glands were removed, weighed, and prepared for his tological analysis. Livers, kidneys, and spleens from all experimental subgroups demonstrated histological discrepancies differing from the same organs in control fetuses. No difference was observed between adrenal glands from experimental fetuses and control fetuses. Statistical analysis revealed that weights of the organs of the experimental and control fetuses differed significantly in only 3 subgroups of kidneys. There was, however, much variation in the weights of the experimental organs. No difference occurred in the weights of experimental fetuses and control fetuses.

Copyright

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