Term of Award
Summer 2017
Degree Name
Master of Science in Applied Physical Science (M.S.)
Document Type and Release Option
Thesis (open access)
Copyright Statement / License for Reuse
This work is licensed under a Creative Commons Attribution 4.0 License.
Department
Department of Chemistry
Committee Chair
John DiCesare
Committee Member 1
Karelle Aiken
Committee Member 2
Christine Whitlock
Abstract
In an attempt to create more effective chemotherapeutic compounds, the naphthoquinone adduct, 12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo[4,5]cyclohepta [1,2 b]naphthalen-5,12-imine (hereafter called TU100) was synthesized. Inspired by its unique and novel mechanism of action, a series of structural derivatives were synthesized to explore structure-activity relationships. The analogues exhibited different cytotoxicity profiles, revealing the indicated regions are involved in cell death induction. Furthermore, the analogues had dramatically different effects on cellular ATP production, suggesting different molecular targets. Synthesis, biological activity, and SAR study of these analogues will be revealed.
OCLC Number
1001573015
Catalog Permalink
https://galileo-georgiasouthern.primo.exlibrisgroup.com/permalink/01GALI_GASOUTH/1r4bu70/alma9916057888202950
Recommended Citation
Alao, Oladotun J., "Synthesis and Biological Activity of Novel Tu100 Derivatives" (2017). Electronic Theses and Dissertations. 1617.
https://digitalcommons.georgiasouthern.edu/etd/1617
Research Data and Supplementary Material
No
