Term of Award
Summer 2016
Degree Name
Master of Science in Applied Physical Science (M.S.)
Document Type and Release Option
Thesis (open access)
Copyright Statement / License for Reuse
This work is licensed under a Creative Commons Attribution 4.0 License.
Department
Department of Chemistry
Committee Chair
Jonathan Arambula
Committee Member 1
Amanda Stewart
Committee Member 2
Worlanyo Gato
Abstract
Gold (I) coordinated N-heterocyclic carbenes containing appended redox cycling moieties were designed and analyzed for their ability to target the antioxidant network via multiple mechanisms in various human cancer cell models. Complexes containing either ferrocene or naphthoquinone redox cycling moieties were screened for inhibition of cell growth, inhibition of thioredoxin reductase (TrxR), and accentuation of exogenous ROS. The cell death pathway employed was determined by flow cytometry via detection of Annexin-V FITC. Furthermore, differential gene expression between treated cells and untreated cells revealed the induction of endoplasmic reticulum stress and unfolded protein response pathways.
Recommended Citation
McCall, R. E. Small Molecule Disruption of ROS-Regulating Pathways in Human Carcinoma. Master's Thesis, Georgia Southern University, Statesboro, GA, 2016.
Research Data and Supplementary Material
No
