Title

Lewis Acid-Catalyzed Csp3-H Functionalization of Methyl Azaarenes with α-Trifluoromethyl Carbonyl Compounds

Document Type

Article

Publication Date

2013

Publication Title

Tetrahedron Letters

DOI

10.1016/j.tetlet.2012.12.013

Abstract

A Lewis acid promoted Csp3–H bond functionalization of methyl azaarenes with α-trifluoromethylated carbonyl compounds is described. Catalytic amounts of Yb(OTf)3 provided a straightforward access to the corresponding trifluoromethylated alcohols in excellent yields up to 94% under mild reaction conditions.